Having worked with DotNetNuke for more than 4 years now, I have performed literally hundreds of installations.  While the installation process has gotten easier over the years as we have beefed up the installation routines, it is still not automatic. Even though I can install DNN in under a couple minutes, I often cut corners.  I usually just give the Asp.Net process account full control of the web application folder and use an sa account in the DB.  Neither of these are great practices, but setting up the correct permissions is a little more tedious...